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What is neutropenia?
Neutropenia is a condition, in which the number of blood neutrophilic
granulocytes (neutrophils), as subgroup of the white blood cells or
leukocytes, respectively, is diminshed.
Congenital neutropenia is a general term used to describe a group of serious but rare inherited hematological disorders, which cause neutropenia with less than 500 neutrophils/mm3 on a continuing basis for many months or years:
In cyclic neutropenia neutrophil counts show a cyclic pattern with a typical cycle length of 21 days. These cycles vary from patient to patient with some individuals being neutropenic during the whole cycle and others who have low neutrophil counts for only a few days and normal blood counts during the rest of the cycle.
Idiopathic neutropenia describes a group of acquired neutropenias including:
The decision on what therapy is best for the patient depends directly on an accurate diagnosis of neutropenia. The SCNIR provides assistance and information on the diagnosis of neutropenia on request.
In addition to antibiotic treatment of bacterial infections caused by neutropenia, cytokines may be applied. The majority of patients with severe chronic neutropenia benefits from a G-CSF therapy. Patients with severe chronic neutropenia may call for an outpatient appointment at the neutropenia consultation of the Department of Pediatric Hematology and Oncology of the Medical School Hannover.
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