Greece
Δημογραφικά
Στοιχεία
| Ονομα: | Ελένη
Α. Παπαδάκη |
|
| Καταγωγή: | Χανιά
Κρήτης |
|
| Ετος γέννησης: | 1963 |
|
| Οικογενειακή κατάσταση: | Εγγαμος,
μητέρα ενός
παιδιού |
|
| Διεύθυνση κατοικίας: | Παπαναστασίου
38, Χανιά, ΤΚ 731.00 |
|
| Τηλέφωνο: | 28210-55.840
/ 6973-323.258 |
|
| Fax: | 2810-394.632 |
|
| Διεύθυνση εργασίας: | Πανεπιστημιακό
Νοσοκομείο
Ηρακλείου |
|
| Αιματολογική
Κλινική |
||
| Τ.Θ.
1352, Σταυράκια,
Ηράκλειο
Κρήτης |
||
| Τηλέφωνο: | 2810-392.427
|
|
| Fax: | 2810-392.426 |
|
| E-mail: | epapadak@med.uoc.gr |
1.1.
Σύνοψη
Βιογραφικών
Στοιχείων
| 1987 | Πτυχίο
Ιατρικής
Σχολής
Πανεπιστημίου
Αθηνών με “Aριστα”. |
|
| 1989 - 1995 |
Ειδικότητα
Αιματολογίας
στην
Αιματολογική
Κλινική του
Πανεπιστημιακού
Νοσοκομείου
Ηρακλείου. |
|
| 1995 | Διδακτορικό
Δίπλωμα
Ιατρικού
Τμήματος Πανεπιστημίου
Κρή-της με τον
βαθμό “Αριστα |
|
| 1996 | Απόληψη
τίτλου
Ειδικότητας
στην
Αιματολογία. |
|
| 2/1997 | Εκλογή σε
θέση Λέκτορος
της
Αιματολογίας
στον Τομέα Παθο-λογίας
του
Πανεπιστημίου
Κρήτης. |
|
| 1999 - 2000 | Ερευνητική συνεργασία ως Research Fellow στο Department of Haematology of
St George’s Hospital Medical School of the University of London ως υπότροφος της ΕΜΒΟ. |
|
| 2001 | Εκλογή
σε θέση
Επίκουρου
Καθηγητή της
Αιματολογίας
στο Ιατρικό
Τμήμα του
Πανεπιστημίου
Κρήτης, θέση
την οποία εξα-κολουθώ
να κατέχω μέχρι
σήμερα. |
|
| 6/2002 - 9/2002 | Ερευνητική
συνεργασία ως Research
Fellow
στο CRC Institute
for
Cancer Studies (University
of Birmingham
Medical
School σε θέματα
Κυτταρικής και
Μοριακής
Βιολογίας με
τρίμηνη
εκπαιδευτική
άδεια από το
Ιατρικό Τμήμα. |
1.2. Μέλος
Ιατρικών
Εταιρειών και
Επιστημονικών
Ομάδων
| 1. | Mέλος
της Ελληνικής
Αιματολογικής
Εταιρείας |
|
| 2. | Τακτικό
Μέλος Τμήματος
Μυελοδυσπλαστικών
Συνδρόμων και
Μυελικής
Ανεπάρ-κειας
της Ελληνικής
Αιματολογικής
Εταιρείας |
|
| 3. | Μέλος της
Ιnternational Society for Experimental Hematology. |
|
| 4. | Μέλος της European Haematology Association |
|
| 5. | Μέλος και
εκπρόσωπος για
την Ελλάδα της Severe
Chronic Neutropenia International
Registry (SCNIR) (Έδρα,
Αννόβερο
Γερμανίας). |
1.3. Ξενόγλωσσες
εργασίες
W-59. Ponchel
F,
Verburg RJ,
Bingham
SJ,
Moore J,
Protheroe
A,
Douglas SH,
PAPADAKI
HA,
Short K,
Masurel
A,
Mcgonagle D,
Snowden
J,
Markham AF,
Ma
D,
Patel P,
van
Laar
JM, Emery
P,
Isaacs JD. IL-7 deficiency in rheumatoid arthritis:
consequences for therapy-induced lymphopenia. Arthr Res Ther 2005; 7: R80-R92.
W-58.
CHRISTOFORIDOY AV, PAPADAKI HA, MARGIORIS AN, ELIOPOULOS GD, TATSANIS C. Expression
of the Tpl2/Cot oncogene in human T-cell neoplasias. Mol Cancer 2004;3: 34
W-57. MEGALAKAKI K, MITSOULI C, PONTIKOGLOY C, IAKOVIDOU J, KOYMAKI
V, ELIOPOULOS GD, PAPADAKI HA.Chronic idiopathic neutropenia preceding polymyalgia rheumatica and acute
myeloid leukaemia. Ann Hematol 2004;83:791-792..
W-56.
PAPADAKI HA, KOSTEAS T, GEMETZI C, DAMIANAKI A, ANAGNOU N, ELIOPOULOS GD.
Acute
myeloid/NK-precursor cell leukemia with trisomy 4 and a novel point mutation in
the extracellular domain of the G-CSF receptor in a patient with chronic
idiopathic neutropenia. Ann Hematol 2004;83:345-348..
W-55. PAPADAKI HA,
TSATSANIS C, CHROSTOFORIDOU A, MALLIARAKI N, MARGIORIS AN, ELIOPOULOS GD.
Alendronate reduces serum TNFα and IL-1β and improves bone mineral density and bone metabolism indices in patients
with chronic idiopathic neutropenia (CIN)-associated osteopenia and
osteoporosis. J
Bone Miner Metab 2004;22:577-587.
W-54. PAPADAKI HA, KOSTEAS T, CHRISTOFORIDOU A, GEMETZI C, ANAGNOU
NP, ELIOPOULOS GD. Low serum gamma-glutamyltranspeptidase (GGT) in patients with
chronic idiopathic neutropenia is not implicated in the pathophysiology of the
disease. Haematologica 2003; 88: ELT32.
W-53.
PAPADAKI
HA,
ELIOPOULOS GD. The role of apoptosis in the pathophysiology of chronic
neutropenias associated with bone marrow failure. Cell Cycle 2003; 2:
447-451 (Invited Review).
W-52.
PERSON RE, LI F-Q, DUAN Z, BENSON KF, WECHSLER J, PAPADAKI HA,
ELIOPOULOS GD, KAUFMAN C, BERTOLONE SJ, NAKAMOTO B, PA-PAYANNOPOULOU T, GRIMES
HL, HORWITZ M. Mutations in the proto-oncogene GFI1 cause human neutropenia and
target ELA2. Nature
Genet 2003; 34: 308-312.
W-51.
PAPADAKI
HA,
HORWITZ M, COULOCHERI SA, PERSON RA, BENSON KF, ELIO-POULOS GD. Low levels of
serum elastase are not associated with mutations in ELA-2 elastase
encoding gene in chronic idiopathic neutropenia. Blood 2003; 101:
2898-2899.
W-50.
PAPADAKI
HA,
ELIOPOULOS AG, KOSTEAS T, GEMETZI C, DAMIANAKI A, KOUTALA H, BUX J, ELIOPOULOS
GD. Impaired
granulocytopoiesis in chronic idiopathic neutropenia is associated with
increased apoptosis of bone marrow myeloid progenitor cells. Blood 2003;
101: 2591-2600.
W-49. PAPADAKI HA.
Autoreactive T-lymphocytes are implicated in the pathogenesis of bone marrow
failure in systemic lupus erythematosus. Leuk
Lymphoma 2003; 44: 1301-1307 (Invited
Review).
W-48. PAPADAKI HA,
XYLOURI I, KATRINAKIS G, FOUDOULAKIS A, KRITIKOS HD, STATHOPOULOS EN, BOUMPAS
DT, ELIOPOULOS GD. Non-Hodgkin’s lymphoma in patients with systemic lupus
erythematosus. Leuk Lymphoma 2003; 44: 275-279.
W-47. KOUMAKI V, PAPADAKI
HA, STEFANAKI K, KATRINAKIS G, KATONIS P, VRENTZOS G, ELIOPOULOS GD.
Increased cell apoptosis in bone marrow trephine biopsies and immunomagnetically
isolated myeloid progenitor cells in patients with chronic idiopathic
neutropenia.
Ann Hematol 2003; 82: 641-645.
W-46. PAPADAKI HA, SKORDILIS P, MINADAKIS G,
ROUSSOMOUSTAKI M, KATRINAKIS G, PSYLLAKI M, TZARDI M, KOUROUMALIS M, ELIOPOULOS
GD. Complete regression of primary
gastric plasmacytoma following Helicobacter
pylori eradication. Ann
Hematol 2003; 82: 589-592.
W-45.
PRASSOULI A, COULOCHERI SA, PONTICOGLOU C, BOULA A, PAPADAKI
HA,
ELIOPOULOS GD. Low
levels
of serum neutrophil elastase inversely correlate with serum α1-antitrypsin in patients with chronic idiopathic
neutropenia. Haema 2003; 6: 352-357.
W-44.
ANDRIOTI C, KATRINAKIS G, NINIRAKI M, COULOCHERI SA, PODICOGLOU C, KOUMAKI
V, ELIOPOULOS GD, PAPADAKI HA. Increased
sensitivity of peripheral blood B-lymphocytes to non-specific polyclonal
activators in patients with chronic idiopathic neutropenia. Haema 2003; 6: 54-60.
W-43.
PAPADAKI HA, KRITIKOS HD, VALATAS V, BOUMPAS DT, ELIOPOULOS GD. Anemia of
chronic disease in rheumatoid arthritis is associated with increased apoptosis
of bone marrow erythroid cells. Improvement following anti-tumor necrosis
factor-α antibody therapy. Blood 2002; 100: 474-482.
W-42.
PAPADAKI HA, KRITIKOS HD, GEMETZI C,
KOUTALA H, MARSH JCW, BOUMPAS DT, ELIOPOULOS GD. Bone marrow stem cell reserve
and function and stromal cell function are defective in rheumatoid arthritis.
Evidence for a tumor necrosis factor-alpha (TNFα)-mediated
effect.
Blood 2002; 99:1610-1619.
W-41.
PAPADAKI HA, MICHELAKAKI H, BUX J,
ELIOPOULOS GD. Autoimmune neutropenia associated with bone marrow sea-blue
histiocytosis. Brit
J Haematol 2002; 118: 931.
W-40.
RIZZO S, SCOPES J, ELEBUTE MO, PAPADAKI HA, GORDON-SMITH EC, GIBSON
FM. Stem cell defect in aplastic anemia: reduced long-term culture-initiating
cells (LTC-IC) in CD34+ cells isolated from aplastic anemia patient
bone marrow.
Hematol J 2002; 3: 230-236.
W-39.
PAPADAKI HA, MARSH JCW, ELIOPOULOS GD.
Bone marrow stem cells and stromal cells in autoimmune cytopenias. Leuk Lymphoma 2002; 43: 753-760 (Invited Review).
W-38. PAPADAKI HA, KOSTEAS T, GEMETZI C,
ALEXANDRAKIS M, ELIOPOULOS GD. Two patients with nonimmune chronic idiopathic
neutropenia of adult developing acute myeloid leukemia with aberrant phenotype
and complex karyotype but no mutations in G-CSF receptor. Ann
Hematol 2002; 81: 50-54.
W-37.
PAPADAKI
HA,
ELIOPOULOS GD. An overview on the diagnosis, classification and differential
diagnosis of chronic neutropenias. Haema 2002; 5: 39-49.
(Invited Review).
W-36. PAPADAKI HA, ELIOPOULOS GD, COULOCHERI S, SPYROPOULOU M, STAVRO-POULOS-GIOKAS C. Increased
frequency of HLA-DRB1*1302 haplotype in patients with nonimmune chronic
idiopathic neutropenia of adult. Blood
2001; 77: 850-851.
W-35. PAPADAKI HA, BOUMPAS DT, GIBSON FM, JAYNE DR, AXFORD JS,
GORDON-SMITH EC, MARSH JCW, ELIOPOULOS GD. Increased apoptosis of bone marrow
CD34+ cells and impaired function of bone marrow stromal cells in
patients with systemic lupus erythematosus. Brit
J Haematol 2001; 115: 167-174.
W-34. PAPADAKI HA,
GIBSON FM, PSYLLAKI M, GORDON-SMITH EC, MARSH JCW, ELIOPOULOS GD. Assessment of
bone marrow stem cell reserve and function and stromal cell function in patients
with severe congenital neutropenia. Eur J Haematol 2001; 67: 245-252.
W-33.
PAPADAKI HA, PALMBLAD J, ELIOPOULOS GD. Nonimmune chronic idiopathic
neutropenia of adult: an overview. Eur J Haematol 2001; 67: 35-44.
W-32.
PALMBLAD J, PAPADAKI HA, ELIOPOULOS GD.
Acute and chronic neutropenia – What is new?
J Intern Med 2001; 250: 476-491 (Invited Review).
W-31. PAPADAKI
HA, CHAROULAKIS NZ,
ELIOPOULOS DG, PSYLLAKI M, ELIOPOULOS GD. Patients with nonimmune chronic
idiopathic neutropenia syndrome have increased splenic volume on
ultrasonography. Clin Lab Haematol
2001; 23: 111-118.
W-30. PAPADAKI
HA, ELIOPOULOS DG,
PONTICOGLOU C, ELIOPOULOS GD. Increased frequency of monoclonal
gammopathy of undetermined significance in patients with nonimmune chronic
idiopathic neutropenia of adult. Int J
Hematol 2001; 73: 339-345.
W-29.
PAPADAKI HA, ELIOPOULOS DG, VALATAS V, ELIOPOULOS GD. Anemia of chronic
disease is the more frequent type of anemia seen in patients with non-immune
chronic idiopathic neutropenia of adult. Ann
Hematol 2001; 80: 195-200.
W-28. PAPADAKI
HA, PSYLLAKI M, ELIOPOULOS
DG, TSIROYIANNI A, ELIOPOULOS GD. Increased frequency and specific
reactivity of serum antinuclear antibodies in patients with nonimmune chronic
idiopathic neutropenia of adult. Acta
Haematol 2001; 105: 13-20.
W-27. PAPADAKI HA,
GIBSON FM, RIZZO S, GORDON-SMITH EC, MARSH JC. Assessment of bone marrow
stem cell reserve and function and stromal cell function in patients with
autoimmune cytopenias. Blood 2000; 96: 3276-3279.
W-26. PAPADAKI HA,
COULOCHERI S, ELIOPOULOS GD. Patients with chronic idiopathic neutropenia of
adult have increased serum concentrations of inflammatory cytokines and
chemokines. Am J Hematol 2000; 65:
271-277.
W-25. PAPADAKI HA,
PALMBLAD J, KAPSIMALI V, ANAGNOU NP, ELIOPOULOS GD. Increased serum IgA and
decreased IgG3 strongly correlate with increased serum TGF-β1 levels in patients with nonimmune chronic
idiopathic neutropenia of adults. Eur J Haematol 2000; 65: 237-244.
W-24. PAPADAKI HA, CHATZIVASSILI A, STEFANAKI K, KOUMAKI V, KANAVAROS P,
ELIOPOULOS GD. Morphologically defined myeloid cell
compartments, lymphocyte subpopulations, and histologycal findings of bone
marrow in patients with nonimmune chronic idiopathic neutropenia of adults. Ann
Hematol 2000; 79: 563-570.
W-23.
PAPADAKI HA, VARDAKIS C, NANAS J, VAIOPOULOS G, ELIOPOULOS GD. Extensive
calcification of pericardium in a patient with primary amyloidosis. Ann
Hematol 2000; 79: 405-406.
W-22. PAPADAKI HA, STEFANAKI K, KANAVAROS P,
KATONIS P, PAPASTATHI H, VALATAS V, STYLIANOY K, ELIOPOULOS GD. Epstein-Barr
virus-associated high-grade anaplastic plasmacytoma in a renal transplant
patient. Leuk Lymphoma 2000; 36:
411-415.
W-21. PAPADAKI HA, KOUROUMALIS EA, STEFANAKI
M, ROUSSOMOUSTAKAKI M, DASKALOYIANNAKI M, REPPA D, ELIOPOULOS GD. Retractile
mesenteritis presented as fever of unknown origin and autoimmune haemolytic
anaemia. Digestion 2000; 61: 145-148.
W-20. PAPADAKI HA,
GIOUREMOU K, ELIOPOULOS GD. Overexpression of neutrophil L-selectin may account
for the enhanced neutrophil extravasation in patients with chronic idiopathic
neutropenia of adults. Haema 2000; 3: 29-35.
W-19.
PAPADAKI HA, GIOUREMOU K, ELIOPOULOS GD. Low frequency of myeloid
progenitor cells in chronic idiopathic neutropenia of adults may be related to
increased production of TGF-β1
by bone marrow stromal cells. Eur J
Haematol 1999; 63: 154-162.
W-18.
PAPADAKI HA, MARGIORIS AN, MILIAKI M,
STERIOPOULOS C, VALATAS W, ELIOPOULOS GD. Chronic
idiopathic neutropenia of adults is associated with decreased bone mineral
density and alterations in bone turnover biochemical markers. Eur
J Haematol 1999; 62: 311-316.
W-17. KANAVAROS P, STEFANAKI K, RONTOGIANNI D, DARIVIANAKI K, VLYCHOU M, PAPADAKI
HA, ELIOPOULOS GD, BAKIRI M, MATSOUKA C, KAKOLYRIS S, GEORGOULIAS V.
Immunohistochemical detection of p53, mdm2, waf1/ p21, and Ki67
proteins in bone marrow biopsies in myelodysplastic syndromes, acute myelogenous
leukaemias and chronic myeloproliferative disorders. Clin Exp Pathol 1999;
47: 231-238.
W-16.
PAPADAKI HA, XYLOURI I, COULOCHERI S, KALMANTI M, KAFATOS A, ELIO-POULOS
GD. Prevalence
of chronic idiopathic neutropenia of adults among an appare-ntly healthy
population living on the island of Crete. Ann Hematol 1999; 78: 293-297.
W-15. PAPADAKI HA. Cell Adhesion Molecules in
Haematology. Haema 1999; 2: 180-191 (Invited Review).
W-14. PAPADAKI HA, ELIOPOULOS GD. Enhanced
neutrophil extravasation may be a contributing factor in the determination of
neutropenia in patients with chronic idiopathic neutropenia of adults. Eur
J Haematol 1998; 61: 272-277.
W-13. PAPADAKI HA, ELIOPOULOS GD. Selective loss of
peripheral blood CD45RO+ T-lymphocytes correlates with increased
levels of serum cytokines and endothelial cell-derived soluble cell adhesion
molecules in patients with chronic idiopathic neutropenia of adults. Ann
Hematol 1998; 77: 153-159.
W-12.
PAPADAKI HA, XYLOURI I, VALATAS W, PETINARAKIS J, KONTOPOULOU I,
ELIOPOULOS GD. Severe
acquired hemophilia A successfully treated with activated recombinant human
factor VII and immunosuppression. Ann
Hematol 1998; 77: 123-125.
W-11.
PAPADAKI HA, COULOCHERI SA, XYLOURI I, CHATZIVASSILI A, KATRINAKIS G,
KARKAVITSAS N, ELIOPOULOS GD. Defective natural killer cell activity of
peripheral blood lymphocytes correlates with the degree of neutropenia in
patients with chronic idiopathic neutropenia of adults. Ann
Hematol 1998; 76: 127-134.
W-10.
VAIOPOULOS G, BOKI K, KAPSIMALI V, COULOCHERI SA, PAPADAKI HA, ELIOPOULOS
GD. Hemoglobin levels correlate with serum soluble CD23 and
TNF-Rs concentration in patients with rheumatoid arthritis. Haematologia
1998; 29: 89-99.
W-09.
PAPADAKI HA, KATRINAKIS G, ELIOPOULOS AG, COULOCHERI S, ALEXANDRAKIS M,
ELIOPOULOS G. Low numbers of peripheral blood natural killer cells in patients
with chronic idiopathic neutropenia of adults are probably due to enhanced
extravasation into the tissues. Haema
1998; 1: 33-40.
W-08.
KYRIAKOU D, PAPADAKI HA, ELIOPOULOS AG, FOUDOULAKIS A, ALEXANDRAKIS M,
ELIOPOULOS GD. Serum soluble IL-6 receptor concentrations correlate with
clinical stages of multiple myeloma defined by serum β2-microglobulin
and C-reactive protein. Int J Hematol
1997; 66: 367-371.
W-07.
PAPADAKI HA, KONSOLAS J, CHATZIVASSILI A, KATRINAKIS G, MARKIDOU F,
FOUDOULAKIS A, ALEXANDRAKIS M, KYRIAKOU D, ELIOPOULOS GD. Inhibition of
mitogen-induced cellular cytotoxicity by serum from patients with multiple
myeloma. Haematologia
1997; 28: 123-130.
W-06.
KYRIAKOU D, PAPADAKI HA, SAKELLARIOU D, ELIOPOULOS AG, KA-PSIMALI V,
ELIOPOULOS GD. Flow-cytometric analysis of peripheral blood lymphocytes in
patients with chronic idiopathic neutropenia of adults. Ann
Hematol 1997; 75: 103-110.
W-05. PAPADAKI HA,
KYRIAKOU
D, FOUDOULAKIS
A,
MARKIDOU
F,
ALE-XANDRAKIS
M, ELIOPOULOS
GD.
Serum
levels of soluble IL-6 receptor in multiple myeloma as indicator of disease
activity. Acta Haematol 1997; 97: 191-195.
W-04. KATRINAKIS G, KYRIAKOU D, PAPADAKI HA,
KALOKYRI I, MARKIDOU F, ELIOPOULOS GD. Defective natural killer-cell activity in
B-cell chronic lymphocytic leukaemia is associated with impaired release of
natural killer cytotoxic factor(s) but not of tumour necrosis factor-α. Acta
Haematol 1996; 96: 16-23.
W-03.
VAIOPOULOS G, KYRIAKOU D, PAPADAKI HA, FESSAS P, ELIOPOULOS GD. Multiple
myeloma associated with autoimmune hemolytic anemia. Haematologica 1994; 79: 249-251.
W-02.
VAIOPOULOS G, KYRIAKOU D, PAPADAKI HA, KAKLAMANIS P, ELIOPOULOS GD.
Defective mitogen-induced cellular cytotoxicity in untreated patients with
active rheumatoid arthritis. Rheumatol
Intern 1994; 14: 103-107.
W-01.
ELIOPOULOS GD, VAIOPOULOS G, KYRIAKOU D, PAPADAKI HA, KATRINAKIS G,
ALEXANDRAKIS M. Impaired release of natural killer cytotoxic factor(s) by
peripheral blood lymphocytes in patients with chronic LGL-proliferative disease.
Haematologica
1993; 78: 219-224.